Prader-Willi Syndrome [wiki] 
, is a rare genetic disorder that creates a chronic hunger feeling that can lead to overeating and life-threatening obesity. So when a visiting nurse went to tender her client, a 900-pound Michigan man who didn't leave his home since 2003, she had to call in firefighters to help her (also the man to seek medical service).
LANSING, Mich. --Firefighters cut a hole in the side of a house and used a forklift to extricate a 900-pound Lansing man from his second-floor bedroom.
A visiting nurse called in rescue workers after determining that the 33-year-old man needed medical help.
Firefighters lowered the man on a platform and slid it onto a flatbed truck to take him to a city hospital.
I think, the morbid obesity of the world's fatest man, Mexico's Manuel Uribe, may also suffer this syndrome.